You can reach Trier via the following autobahns:

A 1 from Saarbruecken (about 1:00 h)
A1 from Kaiserslautern (about 1:15 h)
A 1 / A 48 from Koblenz (about 1:15 h)
A 1 / A 48 from Koeln (Cologne) (about 2:00 h)
A 64 from Luxembourg (about 0:30 h)

The following Bundesstrassen (highways) go to Trier:

through the Eifel:
B 51 from Pruem / Bitburg
along the Saar:
B 51 from Saarbruecken
Moselle Wine Road: (Moselweinstrasse):
B 49 / B 53 from Cochem / Bernkastel-Kues
Hunsrueckhoehenstrasse:
B 327 / B 52 from the Hunsrueck
along the Moselle:
B 419 / B 51 from France / Luxembourg